Disease landscape

Advanced Solid Tumor clinical trials

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1,234 active trials 814 recruiting 4 Phase 3 640 sponsors 171 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 52 of 171 changes on 20 trials

2026-08-26
critical
Trial terminated
Trial terminated: Business decision
Enrollment reduced: 408 → 49 participants
Primary completion moved earlier: 2025-12-30 → 2025-04-30
Completion moved earlier: 2026-12-30 → 2026-04-30
NCT05718219 Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of SIM0348 in… · Jiangsu Simcere Pharmaceutical Co., Ltd. · Phase 1
2026-08-22
critical
Recruitment suspended
Recruitment suspended: The sponsor is temporarily pausing the trial to evaluate existing clinical data for long-term benefit-risk and opt...
NCT05279300 A Study of CS5001 in Patients With Advanced Solid Tumors and Lymphomas · CStone Pharmaceuticals · Phase 1
2026-08-07
critical
Trial terminated
Trial terminated: Study terminated due to various reasons impacting the feasibility of future clinical development
Primary completion moved earlier: 2025-12 → 2025-01-01
Completion moved earlier: 2025-12 → 2025-01-01
NCT05226507 A Phase 1 Clinical Study of NXP800 in Subjects With Advanced Cancers and Expansion in… · Nuvectis Pharma, Inc. · Phase 1
2026-08-04
critical
Trial terminated
Trial terminated: Business Decision
Completion moved earlier: 2026-03-31 → 2026-01-09
NCT03843359 A First Time in Human (FTIH) Study of GSK3745417 Administered to Participants With… · GlaxoSmithKline · Phase 1
2026-08-28
critical
Primary completion pushed: 2026-04 → 2027-08
NCT05150691 A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors · DualityBio Inc. · Phase 1/2
2026-08-28
critical
Primary completion pushed: 2025-07-30 → 2026-12-30
Completion pushed: 2025-07-30 → 2026-12-30
NCT06299124 A Phase I Study of RGT-419B in Patients With HR-Positive, HER2-Negative Advanced Breast… · Regor Pharmaceuticals Inc. · Phase 1
2026-08-27
notable
Primary completion pushed: 2027-01-11 → 2027-04-26
Completion pushed: 2027-07-30 → 2027-09-06
NCT06659341 A Phase I Study of BAY3498264 Given Together With Sotorasib in Participants Who Have… · Bayer · Phase 1
2026-08-25
critical
Primary completion pushed: 2027-07 → 2031-12-31
Completion pushed: 2027-07 → 2031-12-31
Trial arms changed: 2 → 3
NCT06417554 A Trial of SHR-A2102 With or Without Antitumor Therapy in Advanced Solid Tumors · Shanghai Hengrui Pharmaceutical Co., Ltd. · Phase 1/2
2026-08-27
critical
Primary completion pushed: 2026-05-29 → 2027-01-29
NCT06607939 ORB-021 In Patients With Advanced Solid Tumors · Orionis Biosciences Inc · Phase 1
2026-08-20
critical
Primary completion pushed: 2026-09-13 → 2027-12-30
Primary endpoint(s) modified
Enrollment increased: 18 → 78 participants
Completion pushed: 2026-09-13 → 2027-12-30
NCT06144671 Phase I/II Clinical Study of GT201 Injection as Monotherapy or in Combination With PD-1… · Grit Biotechnology · Phase 1/2
2026-08-14
critical
Primary completion pushed: 2026-03 → 2027-03
Completion pushed: 2026-03 → 2027-03
NCT05288205 Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors… · Allist Pharmaceuticals, Inc. · Phase 1/2
2026-08-12
critical
Primary completion pushed: 2026-10 → 2027-09
Trial sites reduced: 32 → 19 locations
Completion pushed: 2026-10 → 2027-09
NCT05592626 A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion… · Marengo Therapeutics, Inc. · Phase 1/2
2026-08-12
critical
Primary completion pushed: 2025-06-30 → 2026-12-30
Sponsor changed: Evopoint Biosciences Inc. → Astellas Pharma Global Development, Inc.
Enrollment closed, study ongoing
Completion pushed: 2025-12-31 → 2027-06-30
NCT06792435 XNW27011 Study of Advanced Solid Tumor Subjects Who Failed Standard Therapies. · Astellas Pharma Global Development, Inc. · Phase 1/2
2026-08-08
notable
Primary completion pushed: 2026-10 → 2027-03
Phase changed: Phase 1 → Phase 1/2
Enrollment increased: 136 → 208 participants
Completion pushed: 2027-03 → 2027-09
Trial arms changed: 6 → 9
NCT06515990 A Study of DM005 in Patients With Advanced Solid Tumors · Doma Biopharmaceutical(Suzhou)Co., Ltd. · Phase 1/2
2026-08-07
critical
Primary completion pushed: 2026-05-31 → 2026-12-31
NCT05944224 A Study to Efficacy and Safety of SPH4336 Monotherapy or in Combination With Cadonilimab… · Shanghai Pharmaceuticals Holding Co., Ltd · Phase 1/2
2026-07-31
critical
Primary completion pushed: 2026-06-12 → 2027-02-28
Completion pushed: 2026-06-12 → 2027-02-28
NCT05267626 Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in… · Aulos Bioscience, Inc. · Phase 1/2
2026-07-30
critical
Primary completion pushed: 2025-11 → 2028-05
Primary endpoint(s) modified
Trial sites expanded: 45 → 54 locations
Completion pushed: 2027-11 → 2028-11
NCT03526835 A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors · Merus B.V. · Phase 1/2
2026-08-22
critical
Primary completion pushed: 2026-08-31 → 2027-08-31
Completion pushed: 2026-08-31 → 2027-08-31
NCT05687136 Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and Tuvusertib… · National Cancer Institute (NCI) · Phase 1
2026-08-07
critical
Primary completion pushed: 2026-06-30 → 2026-12-31
NCT06049212 Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in… · Merck Sharp & Dohme LLC · Phase 1
2026-08-06
critical
Primary completion pushed: 2026-09-20 → 2027-09-20
NCT07294872 A Study of TIL in Advanced Solid Tumors (CZ) · Shanghai Juncell Therapeutics · Phase 1

Active trials by phase

Early Phase 1
47
Phase 1
649
Phase 1/2
403
Phase 2
92
Phase 2/3
2
Phase 3
2
Phase 4
2
Not charted: 37 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,234

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06408688 Safety and Modulation of Adaptive Immunity by Iscador® Qu Viscum Album Extract in… University Hospital, Basel, Switzerland Recruiting 2024-12-27
NCT06824792 Optimal Standard Treatment Selection for Solid Tumor Patients by Biologically-informed… NING LI Not Yet Recruiting 2025-02-13
Phase 3
NCT06658353 Phase III Clinical Study of VC004 in Patients With Localized Advanced/ Metastatic Solid… Jiangsu vcare pharmaceutical technology co., LTD Recruiting 2026-07-27
NCT07659379 Gotistobart Long Term Extension (LTE) Study OncoC4, Inc. Enrolling by Invitation 2026-08-24
Phase 2/3
NCT07290088 Phase II/III Trial of PRL3-Zumab in Advanced Solid Tumor Patients Intra-IMMUSG Pte Ltd Recruiting 2026-04-16
NCT03755739 Trans-Artery/Intra-Tumor Infusion of Checkpoint Inhibitors Plus Chemodrug for… Second Affiliated Hospital of Guangzhou Medical University Recruiting 2024-06-25
Phase 2
NCT07209111 A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors… Merck Sharp & Dohme LLC Recruiting 2026-08-21
NCT06172478 A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors Daiichi Sankyo Recruiting 2026-08-21
NCT05327010 Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in… National Cancer Institute (NCI) Recruiting 2026-08-20
NCT05564377 Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced… National Cancer Institute (NCI) Recruiting 2026-08-19
NCT07669415 A Study of LM-168 Combined With Other Anti-tumor Treatments in Participants With Advanced… LaNova Medicines Limited Recruiting 2026-07-30
NCT02029001 Adapting Treatment to the Tumor Molecular Alterations for Patients With Advanced Solid… Centre Leon Berard Recruiting 2026-07-29
NCT03907475 Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid… National Cancer Institute (NCI) Recruiting 2026-07-24
NCT07172919 A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With… Amgen Recruiting 2026-07-23
NCT06889610 A Phase II Clinical Study of Multimodal Ablation Combined With Systemic Drug Therapy for… Fudan University Recruiting 2026-07-13
NCT07697937 YH02 Injection for Intra-tumor Injection Therapy in Advanced Solid Tumors With… Tianjin First Central Hospital Recruiting 2026-07-13
NCT06760819 A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets… Bayer Recruiting 2026-07-07
NCT07671534 Metronomic Gemcitabine, Mitomycin C, and Thalidomide for Advanced Solid Tumors Sarcoma Oncology Research Center, LLC Recruiting 2026-06-26
NCT06730347 A Study of Lorigerlimab in Participants With Advanced Solid Tumors MacroGenics Recruiting 2026-06-02
NCT02693535 TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a… American Society of Clinical Oncology Recruiting 2026-05-29
NCT07581912 Neoadjuvant Treatment of Fulzerasib Plus Cetuximab N01 in KRAS G12C Mutated Locally… Zhejiang University Recruiting 2026-05-12
NCT06416007 Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors University of Cincinnati Recruiting 2026-05-04
NCT07058948 Spatially Fractionated Radiotherapy Combined With Immunotherapy for Advanced Solid Tumors Tianjin Medical University Cancer Institute and Hospital Recruiting 2026-04-29
NCT03810339 Toripalimab(JS001) as Monotherapy in Participants With POLE or POLD-1 Mutated and… Sun Yat-sen University Recruiting 2026-04-23
NCT06365840 A Study of IMC-001 In Patients With Metastatic Or Locally Advanced TMB-H Solid Tumor ImmuneOncia Therapeutics Inc. Recruiting 2026-04-17

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