Individuals with MS experience significantly high levels of depression which are higher than in any other chronic illness or neurological disorder. Depression can occur at any point in the course of the disease. Cognitive behavioural therapy (CBT) has been found to be effective in treating depression in people with MS. However, many individuals with MS who would benefit from CBT for depression do not participate in face-to-face treatment due to lack of clinician referral, accessibility, modality preference, cost, and mobility and travel issues due to health reasons. Given the acceptability and preference for telehealth treatment options, digital-based psychological interventions can be another appealing treatment option as these programs have the ability to deliver interactive CBT treatments for depression to individuals with MS at a time and location convenient to the individual. The current trial proposes to test the acceptability, effectiveness, satisfaction and cost-effectiveness of an 8-week online depression intervention targeting individuals with multiple sclerosis and compare this intervention with an 8-week online health and wellbeing in MS informational intervention.

Trial Details

NCT Number	NCT07875309
Lead Sponsor	University of Melbourne
Conditions (from sponsor)	Depression and Anxiety Symptoms, Multiple Sclerosis
Related terms	Anxiety Disorders, Depression, Multiple Sclerosis
Enrollment	240 participants
Start Date	Nov 1, 2026
Primary Completion	Jun 1, 2027 (estimated)
Study Completion	Jun 30, 2027 (estimated)
Updated on ClinicalTrials.gov	Oct 15, 2026