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Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

StatusRecruiting
PhasePhase 2
Started2026-07-28
View on ClinicalTrials.gov ↗

Amendment history

2026-09-30
minor
Trial sites expanded: 5 → 18 locations
2026-08-18
notable
Study Status, Contacts/Locations v1
Recruitment opened
Trial sites expanded: 0 → 5 locations
Start dateestimated 2026-07-29→confirmed 2026-07-28
2026-06-29
minor
Original filing
148 trials monitored
See 16 trials at risk
3,523 trials monitored
See 133 trials at risk
This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this drug is compared to placebo and how easily the body can accept this drug at different doses and dosing schedules without causing side effects, as well as how the drug is processed in the body by participants with overweight or obesity but do not have diabetes. The study is looking at: * What side effects the study drug might cause * How much study drug is in the blood at different times * How well the study drug works * What effects the study drug may have on the body at different dosing schedules * If the body makes antibodies to the study drug as this may cause the study drug to not work as well
Trial Details
NCT Number NCT07685808
Lead Sponsor Regeneron Pharmaceuticals
Conditions Overweight or Obesity
Enrollment 360 participants
Start Date 2026-07-28
Primary Completion 2028-01-21 (estimated)
Study Completion 2028-01-21 (estimated)
Updated on ClinicalTrials.gov 2026-09-29