Clinical Trial

Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals

Not Yet Recruiting

Summary

This randomized controlled trial aims to investigate the effects of a 24-week home-based progressive resistance exercise program combined with tirzepatide treatment on skeletal muscle mass, muscle quality, and functional capacity in overweight and obese individuals. A total of 108 participants initiating tirzepatide therapy will be randomized to either exercise plus pharmacotherapy or pharmacotherapy alone. The primary outcome is change in thigh muscle thickness and echo intensity assessed by ultrasonography.

Protocol Amendment History 1 amendment

This ClinicalTrials.gov record has been amended once since 2026-05-21.

Trial Details

NCT Number	NCT07609160
Lead Sponsor	Acibadem University
Conditions	Obesity, Sarcopenia, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities
Enrollment	108 participants
Start Date	2026-11-01
Primary Completion	2027-11-30 (estimated)
Study Completion	2028-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-04