Clinical Trial

Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia

Name: Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia — clinical trial record (NCT07279740)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: PRIME

Recruiting Phase 2

View on ClinicalTrials.gov →

Summary

This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed AD/vascular dementia

Trial Details

NCT Number	NCT07279740
Lead Sponsor	Sunnybrook Health Sciences Centre Collaborators: Alzheimer Society of Canada, Sunnybrook Research Institute, Brain Canada
Conditions	Alzheimer s Disease, Alzheimer Dementia (AD), Alzheimer Dementia, Alzheimer Disease, Apathy, Apathy in Dementia
Enrollment	12 participants
Start Date	2026-01
Primary Completion	2027-10-01 (estimated)
Study Completion	2027-10-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-12