Clinical Trial

Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers

Enrolling by Invitation
View on ClinicalTrials.gov →
Record status
This record was last updated February 11, 2026 (before its estimated March 22, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers. Heart rate (HR), heart rate variability (HRV), and brain activity will be measured as participant-caregiver dyads listen to preferred and improvised music performed by professional musicians. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), behavioral, surveys, and physiological monitoring to study the impact of live music on anxiety in AD and inter-dyad synchrony.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-04-15.
Status change: Recruiting → Enrolling by Invitation 2026-02-09
Trial Details
NCT Number NCT06940687
Lead Sponsor Yale University
Collaborators: Renée Fleming Foundation, Howard University, NeuroArts Blueprint Initiative
Conditions Alzheimer Disease, Dementia, Mild Cognitive Impairment, Peer-bonded Caregiver, Caregiver
Enrollment 60 participants
Start Date 2025-01-28
Primary Completion 2026-03-22 (estimated)
Study Completion 2026-03-22 (estimated)
Updated on ClinicalTrials.gov 2026-02-11