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TRIUMPH-5NCT06662383

A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity

StatusActive, Not Recruiting
PhasePhase 3
Primary completion (estimated)
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Record History

All 10 versions: 9 with changes below, 1 re-verified with no change. See every version on ClinicalTrials.gov ↗

  1. Primary completion moved earlier from Dec 2026 to Nov 2026v10
  2. Primary and study completion dates: Apr 2027 to Dec 2026v8
  3. Trial status: Recruiting to Active, Not Recruiting
    • Study sites: 66 to 65
    v7
  4. Site details revised at 66 of 66 sitesv6
  5. Site details revised at 66 of 66 sitesv5
Show 3 earlier versionsHide 3 earlier versions
  1. Study sites revised (66)v4
  2. Study Status, Referencesv3
  3. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 1 to 66
    • Start date changed from estimate of Dec 2024 to Nov 1, 2024
    v2
  1. Study First Submitted
  • Notable: the plan changed
  • Minor: routine updates

Endpoints

Primary

Percent Change from Baseline in Body Weight
Timeframe: Baseline, Week 80

Secondary (9)

Change from Baseline in Body Mass Index (BMI)
Change from Baseline in Waist Circumference
Percent Change from Baseline in Total Cholesterol
Percent Change from Baseline in Triglycerides
Change from Baseline in Systolic Blood Pressure (SBP)
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Change from Baseline in Diastolic Blood Pressure (DBP)
Change from Baseline in Hemoglobin A1c (HbA1c)
Percent Change from Baseline in Fasting Insulin
Change from Baseline in Impact of Weight on Quality of Life-Lite Clinical Trials Version (IWQOL-Lite-CT)

Arms and interventions

RetatrutideExperimental

Participants will receive retatrutide administered subcutaneously (SC)

TirzepatideActive comparator

Participants will receive tirzepatide administered SC

Drugs: Retatrutide, Tirzepatide

Sites

65 sites in 5 countries

United States 40, Poland 10, Germany 9, Argentina 5, Puerto Rico 1