Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study

This is a multicentre, single-arm, feasibility study in adolescents with T2DM and obesity to investigate the recruitment and retention rates to a study using Low Energy Diets(LED). It will also provide estimates of weight loss needed to bring about remission to inform a larger randomised study. In addition a subgroup of participants and their parents/carers undertaking a period of LED will be interviewed to understand the participants experience of taking part. Two further groups will also be interviewed: participants and their parents/carers who have declined to take part in the LED to understand their motivations and barriers and healthcare practitioners who have participated in conducting the trial to understand their experience of the study.

NCT Number	NCT06572345
Lead Sponsor	Nottingham University Hospitals NHS Trust Collaborators: Diabetes UK
Conditions	Pediatric Obesity, Type 2 Diabetes
Enrollment	73 participants
Start Date	2025-06-30
Primary Completion	2028-05-29 (estimated)
Study Completion	2028-05-29 (estimated)
Updated on ClinicalTrials.gov	2026-07-09