Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

NCT Number	NCT06273527
Lead Sponsor	University of California, San Diego
Conditions	Anxiety Disorders, Depression, Post Traumatic Stress Disorder
Enrollment	128 participants
Start Date	2024-10-01
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-08-01 (estimated)
Updated on ClinicalTrials.gov	2025-10-24