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Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

Study acronym: DIAN-TU
StatusActive, Not Recruiting
PhasePhase 2/3
Started2021-12-22
View on ClinicalTrials.gov ↗
To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related biomarkers and slows the rate of progression of cognitive or clinical impairment.

Amendment record

Amended 11 times since 2022-02-24; most recent filed 2026-07-23. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-31.

2026-07-23
Amendment Study Status v11
2026-02-11
Amendment Study Status, Contacts/Locations v10
2025-11-10
Amendment Study Status, Oversight, Contacts/Locations v9
2025-07-30
Amendment Study Status, Oversight, Contacts/Locations v8
2025-03-31
Amendment Study Status v7
2024-07-01
Amendment Recruiting→Active, Not Recruiting Study Status, Study Design, Contacts/Locations v6
2024-02-20
Amendment Study Status, Contacts/Locations v5
2023-05-10
Amendment Study Status, Contacts/Locations v4
2023-04-03
Amendment Study Status, Contacts/Locations v3
2022-12-13
Amendment Study Status, Contacts/Locations v2
2022-08-04
Amendment Study Status, Contacts/Locations v1
2022-02-24
Original filing
Trial Details
NCT Number NCT05269394
Lead Sponsor Washington University School of Medicine
Collaborators: Alzheimer's Association, National Institute on Aging (NIA), Accelerating Medicines Partnership (AMP), Eisai Inc.
Conditions Alzheimers Disease, Dementia, Alzheimers Disease, Familial
Enrollment 197 participants
Start Date 2021-12-22
Primary Completion 2028-04 (estimated)
Study Completion 2028-07 (estimated)
Updated on ClinicalTrials.gov 2026-07-27