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Verastem, Inc. clinical trial pipeline

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10 active trials 5 recruiting 1 Phase 3 5 disease areas 1 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-11

What changed in the last 30 days

1 trial changed in the last 30 days: 0 stopped, 0 with notable changes, 1 with a minor change only.

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

Active trials by phase

Phase 1/2
3
Phase 2
6
Phase 3
1

Active trials

NCT IDTitleConditionStatusUpdated
Phase 3
NCT06072781 A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous… Low Grade Serous Ovarian Cancer Recruiting 2026-10-07
Phase 2
NCT07644559 A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer Pancreatic Ductal Adenocarcinoma (PDAC) Recruiting 2026-10-09
NCT07659795 A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer Colorectal Cancer Recruiting 2026-10-09
NCT07659782 A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer Recruiting 2026-10-07
NCT07747506 Continued Access to Avutometinib in Combination With Defactinib in Patients With… Low Grade Ovarian Serous Adenocarcinoma Not Yet Recruiting 2026-08-05
NCT06682572 A Study of Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in… Low Grade Serous Ovarian Cancer Active, Not Recruiting 2025-12-17
NCT04625270 A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent… Low Grade Ovarian Serous Adenocarcinoma Active, Not Recruiting 2025-01-29
Phase 1/2
NCT07020221 A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors Pancreatic Ductal Adenocarcinoma Recruiting 2026-04-22
NCT05074810 Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS… Non Small Cell Lung Cancer Active, Not Recruiting 2026-01-12
NCT05669482 Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in… KRAS Activating Mutation Active, Not Recruiting 2025-09-02

Disease areas by active trials

Ovarian Cancer (4) · Lung Cancer (3) · Non-Small Cell Lung Cancer (NSCLC) (3) · Pancreatic Cancer (3) · Colorectal Cancer (2)

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