| Detected | Trial | Change |
|---|---|---|
| 2026-08-13 | NCT06789913 A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children… |
Trial sites expanded: 34 -> 40 locations |
| 2026-08-06 | NCT06982521 Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for… |
Trial sites expanded: 211 -> 222 locations |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT06982521 | Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for… | PIK3CA Mutation | Recruiting |
| Phase 2 | |||
| NCT06789913 | A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children… | PIK3CA-Related Overgrowth Spectrum (PROS) | Recruiting |
| Phase 1 | |||
| NCT05216432 | First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in… | PIK3CA Mutation | Recruiting |
| NCT07584226 | A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors | Advanced NRAS-Mutant Melanoma | Recruiting |