Edwards Lifesciences clinical trial pipeline

7 trials changed in the last 30 days: 0 stopped, 4 with notable changes, 3 with minor changes only.

1. Notable

   ENCIRCLE · ENCIRCLE Trial

   Primary completion pushed from Feb 28, 2027 to Oct 10, 2027

   Also in this update: Enrollment closed, study ongoing; Trial sites reduced: 68 → 54 locations

   Edwards Lifesciences·Not applicable· NCT04153292· Registry history of NCT04153292 on ClinicalTrials.gov (opens the registry)

   Oct 6, 2026

2. Notable

   ALT-FLOW US · - Edwards APTURE Transcatheter Shunt System

   Primary completion pushed from Dec 15, 2023 to Apr 2027

   Also in this update: Enrollment reopened; Enrollment increased: 71 → 90 participants

   Edwards Lifesciences·Not applicable· NCT03523416· Registry history of NCT03523416 on ClinicalTrials.gov (opens the registry)

   Oct 2, 2026

3. Notable

   INSPIRIS China · PMCF Study

   Primary completion pushed from Dec 2028 to Mar 2034

   Also in this update: Study completion pushed from Dec 2029 to Dec 2034

   Edwards Lifesciences·Not specified· NCT05404880· Registry history of NCT05404880 on ClinicalTrials.gov (opens the registry)

   Oct 2, 2026

4. Notable

   TWIST-EFS · TVMR With the INNOVALVE System Trial - Early…TWIST-EFS · TVMR With the INNOVALVE System Trial - Early Feasibility Study

   Primary completion pushed from Jul 1, 2026 to Jul 1, 2028

   Also in this update: Primary endpoint(s) modified; Enrollment increased: 65 → 85 participants

   Edwards Lifesciences·Not applicable· NCT04919980· Registry history of NCT04919980 on ClinicalTrials.gov (opens the registry)

   Sep 21, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.