Drug Pipeline

Zimberelimab Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
28
Active Studies
10
Recruiting
3
Phase 3
10
Top Sponsors
5
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-06 NCT05891171
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
date change Primary completion pushed: 2026-03 -> 2027-09
2026-06-06 NCT05891171
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
date change Completion pushed: 2026-03 -> 2027-09
2026-06-02 NCT05633667
Study of Novel Treatment Combinations in Patients With Lung Cancer
overall status: "Recruiting" → "Active Not Recruiting"
2026-06-02 NCT05633667
Study of Novel Treatment Combinations in Patients With Lung Cancer
Enrollment reduced: 270 -> 192 participants
2026-06-02 NCT05633667
Study of Novel Treatment Combinations in Patients With Lung Cancer
Trial sites reduced: 100 -> 89 locations
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-06-02 NCT07619313 AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients… Phase 1 Not Yet Recruiting
Active Studies by Phase
Phase 3
3
Phase 2
14
Phase 1/2
1
Phase 1
9
Early Phase 1
1
Active Trials — top 25 of 28
NCT IDTitleConditionStatus
Phase 3
NCT06431633 Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer… Lung Diseases Recruiting
NCT05502237 Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With… Non-small Cell Lung Cancer Active, Not Recruiting
NCT05568095 A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus… Advanced Upper Gastrointestinal Tract Adenocarcinoma Active, Not Recruiting
Phase 2
NCT06048133 Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced… Biliary Tract Carcinoma Recruiting
NCT06048484 Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma Pancreatic Ductal Adenocarcinoma Recruiting
NCT03547973 Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be… Metastatic Urothelial Cancer Recruiting
NCT07397611 Pre-NEOSHIFT-RCC: Neoadjuvant HIF-Inhibitor Immunotherapy in RCC Renal Cell Carcinoma Recruiting
NCT06727565 Study of Novel Treatment Combination Therapies in Participants With Head and Neck… Head and Neck Squamous Cell Carcinoma Active, Not Recruiting
NCT05335941 A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928… Urothelial Carcinoma Active, Not Recruiting
NCT05824468 Zimberelimab Plus Lenvatinib After Progression on Prior Immune Checkpoint Inhibitors for… Cervical Cancer Active, Not Recruiting
NCT06133517 PeRioperative Immunotherapy Combined With Sacituzumab Govitecan in Muscle Invasive… Urothelial Bladder Carcinoma Active, Not Recruiting
NCT05130177 Zimberelimab (AB122) With TIGIT Inhibitor Domvanalimab (AB154) in PD-1… Melanoma Active, Not Recruiting
NCT04736173 Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer Non Small Cell Lung Cancer Active, Not Recruiting
NCT05633667 Study of Novel Treatment Combinations in Patients With Lung Cancer Lung Cancer Active, Not Recruiting
NCT05676931 Study With Various Immunotherapy Treatments in Participants With Lung Cancer Advanced Non-Small Cell Lung Cancer Active, Not Recruiting
NCT05329766 A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in… Gastrointestinal Tract Malignancies Active, Not Recruiting
NCT04791839 Safety and Efficacy of Zimberelimab (AB122) in Combination With Domvanalimab (AB154) and… Non Small Cell Lung Cancer Active, Not Recruiting
Phase 1/2
NCT05688215 Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of… Borderline Resectable Pancreatic Adenocarcinoma Recruiting
Phase 1
NCT05007782 Study of Denikitug (GS-1811) Given Alone or With Zimberelimab in Adults With Advanced… Advanced Solid Tumor Recruiting
NCT06759649 A Clinical Trial to Assess COM503 in Participants With Advanced Solid Malignancies Neoplasm Recruiting
NCT06532565 Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors Advanced Solid Tumors Recruiting
NCT05536141 A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma… Clear Cell Renal Cell Carcinoma Recruiting
NCT05840224 Study of GS-4528 in Adults With Solid Tumors Solid Tumor Active, Not Recruiting
NCT06082960 Study of GS-9911 With or Without Antibody Treatment for Adults With Solid Tumors Solid Tumors Active, Not Recruiting
NCT04104672 A Study to Evaluate the Safety and Tolerability of AB680 in Participants With… Advanced Pancreatic Cancer Active, Not Recruiting
Sponsors Running Zimberelimab Trials
Disease Areas
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