Drug Pipeline

Ivosidenib Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
21
Active Studies
16
Recruiting
4
Phase 3
10
Top Sponsors
2
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-05 NCT07260175
Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in…
Trial sites expanded: 8 -> 12 locations
2026-05-29 NCT04195555
Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic…
date change Completion pushed: 2026-05-09 -> 2027-05-09
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-05-26 NCT07607418 Ivosidenib as Maintenance Therapy in Transplant-Ineligible IDH1-mutated AML and HR-MDS Phase 2 Recruiting
Active Studies by Phase
Phase 3
4
Phase 2
10
Phase 1/2
4
Phase 1
3
Active Trials
NCT IDTitleConditionStatus
Phase 3
NCT06127407 Ivosidenib in Participants With Locally Advanced or Metastatic Conventional… Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen Recruiting
NCT05907057 An Open-label Phase 3b Study of Ivosidenib in Combination With Azacitidine in Adult… Acute Myeloid Leukemia (AML) Recruiting
NCT06465953 Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With… Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) Recruiting
NCT05615818 Personalized Medicine for Advanced Biliary Cancer Patients Biliary Tract Neoplasms Recruiting
Phase 2
NCT07392242 A Study of the Combination of Ivosidenib, Azacitidine, and Venetoclax Followed by… Acute Myeloid Leukemia Recruiting
NCT06707493 Ivosidenib as Post-HSCT Maintenance for AML IDH1 Mutation Recruiting
NCT04493164 CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or… Acute Myeloid Leukemia With Gene Mutations Recruiting
NCT07607418 Ivosidenib as Maintenance Therapy in Transplant-Ineligible IDH1-mutated AML and HR-MDS AML (Acute Myeloid Leukemia) Recruiting
NCT07548710 Study of SA+X in the Treatment of Newly Diagnosed AML Acute Myeloid Leukemia Recruiting
NCT07260175 Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in… Cholangiocarcinoma Recruiting
NCT05401097 IDH Targeted/Non- Targeted vs Non-targeted/IDH-targeted Approaches in the Treatment of… Acute Myeloid Leukemia Recruiting
NCT04278781 AG-120 in People With IDH1 Mutant Chondrosarcoma Chondrosarcoma Active, Not Recruiting
NCT04195555 Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic… Recurrent Ependymoma Active, Not Recruiting
NCT03155620 Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed… Advanced Malignant Solid Neoplasm Active, Not Recruiting
Phase 1/2
NCT03471260 Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1… Acute Myeloid Leukemia Recruiting
NCT06501625 Ivosidenib Plus Durvalumab and Gemcitabine/Cisplatin as First-Line Therapy in… Locally Advanced, Unresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation Recruiting
NCT04774393 Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for… Acute Myeloid Leukemia Recruiting
NCT02677922 A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase… Leukemia, Myeloid, Acute Active, Not Recruiting
Phase 1
NCT05010772 Decitabine Alone or in Combination With Venetoclax, Gilteritinib, Enasidenib, or… Acute Myeloid Leukemia Recruiting
NCT05756777 A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute… Acute Myeloid Leukemia (AML) Recruiting
NCT02632708 Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy… Newly Diagnosed Acute Myeloid Leukemia (AML) Active, Not Recruiting
Sponsors Running Ivosidenib Trials
Disease Areas
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