Disease landscape

Myelofibrosis clinical trials

Get alerts when Myelofibrosis trials change

143 active trials 85 recruiting 14 Phase 3 88 sponsors 15 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days

2026-08-21
critical
Primary completion pushed: 2027-09-16 → 2032-04-05
NCT02386800 CINC424A2X01B Rollover Protocol · Novartis Pharmaceuticals · Phase 4
2026-08-18
critical
Primary completion pushed: 2026-02-01 → 2026-12-24
Completion pushed: 2026-06-30 → 2026-12-30
NCT06001385 HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced… · Center for International Blood and Marrow Transplant Research · Phase 2
2026-08-27
notable
Enrollment reduced: 36 → 30 participants
Enrollment closed, study ongoing
NCT05371964 A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity… · Geron Corporation · Phase 1
2026-08-08
notable
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
NCT07708272 QT Interval/Corrected QT Interval (QT/QTc) Clinical Study to Evaluate the Cardiac Safety… · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Phase 1
2026-08-12
notable
Recruitment resumed after suspension
Enrollment increased: 62 → 78 participants
NCT06661915 A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative… · National Cancer Institute (NCI) · Phase 2
2026-08-18
notable
Recruitment opened
NCT07302776 TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT · Stanford University · Phase 1
2026-09-01
minor
Trial sites expanded: 53 → 56 locations
NCT07357727 A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF) · Novartis Pharmaceuticals · Phase 3
2026-08-11
notable
Primary completion pushed: 2026-10-19 → 2026-11-19
Completion pushed: 2028-10-19 → 2028-11-19
NCT06361641 Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes · University Hospital, Angers
2026-08-28
minor
Trial sites expanded: 49 → 53 locations
NCT07357727 A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF) · Novartis Pharmaceuticals · Phase 3
2026-08-19
minor
Trial sites expanded: 30 → 47 locations
NCT07357727 A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF) · Novartis Pharmaceuticals · Phase 3
2026-08-14
minor
Trial sites expanded: 2 → 73 locations
NCT06468033 P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk · PharmaEssentia · Phase 3

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-06 NCT07750574 Flonoltinib Maleate Oral Regimens in Patients With Myelofibrosis Chengdu Zenitar Biomedical Technology Co., Ltd new Phase 2

Active trials by phase

Early Phase 1
3
Phase 1
33
Phase 1/2
17
Phase 2
41
Phase 2/3
1
Phase 3
13
Phase 4
2
Not charted: 33 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 143

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07498205 Comparing Momelotinib and Ruxolitinib in People With Untreated Myelofibrosis and Low… SWOG Cancer Research Network Not Yet Recruiting 2026-08-28
NCT02386800 CINC424A2X01B Rollover Protocol Novartis Pharmaceuticals Active, Not Recruiting 2026-08-20
Phase 3
NCT07357727 A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF) Novartis Pharmaceuticals Recruiting 2026-09-01
NCT07623161 A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are… Takeda Recruiting 2026-08-24
NCT04064060 A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other… Celgene Recruiting 2026-07-01
NCT06351631 A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017) Merck Sharp & Dohme LLC Recruiting 2026-04-02
NCT05198960 AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic… University Hospital, Brest Recruiting 2026-03-20
NCT06479135 Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With… Kartos Therapeutics, Inc. Recruiting 2025-09-25
NCT06468033 P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk PharmaEssentia Active, Not Recruiting 2026-08-13
NCT04603495 Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2) Novartis Pharmaceuticals Active, Not Recruiting 2026-07-17
NCT04717414 An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With… Celgene Active, Not Recruiting 2026-07-16
NCT04576156 A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of… Geron Corporation Active, Not Recruiting 2026-07-08
NCT03165734 A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia… Swedish Orphan Biovitrum Active, Not Recruiting 2026-04-30
NCT04562389 Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis Karyopharm Therapeutics Inc Active, Not Recruiting 2026-04-09
NCT04468984 Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best… AbbVie Active, Not Recruiting 2026-01-09
Phase 2/3
NCT07539779 Luspatercept in Preventing Poor Erythroid Engraftment for Hematological Malignancies With… Nanfang Hospital, Southern Medical University Not Yet Recruiting 2026-04-20
Phase 2
NCT06661915 A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative… National Cancer Institute (NCI) Recruiting 2026-09-01
NCT06345495 High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients… M.D. Anderson Cancer Center Recruiting 2026-08-20
NCT07228624 Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With… Fred Hutchinson Cancer Center Recruiting 2026-08-19
NCT07394153 Pacritinib For Bone Marrow Fibrosis In Patients With Myelofibrosis Who Have… Grupo Español de Enfermedades Mieloproliferativas Crónicas PH Negativas Recruiting 2026-07-28
NCT04370301 Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or… Fred Hutchinson Cancer Center Recruiting 2026-07-20
NCT07551427 A Clinical Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of TQ05105… Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Recruiting 2026-07-15
NCT05805605 Allo HSCT Using RIC and PTCy for Hematological Diseases Masonic Cancer Center, University of Minnesota Recruiting 2026-07-06
NCT03314974 Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders Masonic Cancer Center, University of Minnesota Recruiting 2026-06-25
NCT05835466 Reparixin in Patients With Myelofibrosis Myeloproliferative Neoplasms Research Consortium… Icahn School of Medicine at Mount Sinai Recruiting 2026-05-06

Top sponsors by active trials in this area

Get alerts when Myelofibrosis trials change
Status changes, date slips, and new sponsor entrants: detected daily, delivered to your inbox.
Start monitoring free