Disease landscape

Myeloproliferative Neoplasm clinical trials

Get alerts when Myeloproliferative Neoplasm trials change

142 active trials 85 recruiting 6 Phase 3 83 sponsors 31 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-08-01
critical
Withdrawn before enrolling
Trial withdrawn: In alignment with company strategic direction.
Enrollment reduced: 70 → 0 participants
NCT06290765 Efficacy and Safety of Ropeginterferon Alfa 2b (P1101) for Patients With Polycythemia Vera · PharmaEssentia · Phase 4
2026-08-18
critical
Withdrawn before enrolling
Trial withdrawn: FDA requested significant changes to the study protocol
Enrollment reduced: 25 → 0 participants
NCT07387354 Pacritinib With Aza for Upfront Myelodysplastic Syndrome · Thomas Jefferson University · Phase 1/2
2026-08-20
critical
Primary completion pushed: 2026-08-31 → 2027-08-31
Completion pushed: 2026-08-31 → 2027-08-31
NCT05600894 Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic… · National Cancer Institute (NCI) · Phase 2
2026-08-18
critical
Primary completion pushed: 2026-02-01 → 2026-12-24
Completion pushed: 2026-06-30 → 2026-12-30
NCT06001385 HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced… · Center for International Blood and Marrow Transplant Research · Phase 2
2026-08-07
critical
Primary completion pushed: 2026-08-31 → 2028-08-31
Completion pushed: 2026-08-31 → 2028-08-31
NCT02861417 Busulfan, Fludarabine Phosphate, and Post-Transplant Cyclophosphamide in Treating… · M.D. Anderson Cancer Center · Phase 2
2026-08-13
critical
Enrollment reduced: 186 → 37 participants
Enrollment closed, study ongoing
NCT06313593 A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With… · Incyte Corporation · Phase 1
2026-08-11
notable
Enrollment reduced: 225 → 160 participants
Enrollment closed, study ongoing
NCT05936359 A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With… · Incyte Corporation · Phase 1
2026-08-12
notable
Recruitment resumed after suspension
Enrollment increased: 62 → 78 participants
NCT06661915 A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative… · National Cancer Institute (NCI) · Phase 2
2026-08-15
notable
Recruitment opened
NCT07384039 Exercise Training in Patients With Myeloproliferative Neoplasms · Hannover Medical School
2026-08-11
notable
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-05 → 2024-04-04
Completion moved earlier: 2028-05 → 2027-04-04
NCT00935090 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer · Barbara Ann Karmanos Cancer Institute
2026-08-11
notable
Primary completion pushed: 2026-10-19 → 2026-11-19
Completion pushed: 2028-10-19 → 2028-11-19
NCT06361641 Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes · University Hospital, Angers
2026-08-01
notable
Primary completion pushed: 2028-08-01 → 2028-09-01
Completion pushed: 2029-08-01 → 2029-09-01
NCT07679334 Phase I Trial of Pacritinib in Combination With Venetoclax and Azacitidine for the… · Roswell Park Cancer Institute · Phase 1
2026-08-14
minor
Trial sites expanded: 2 → 73 locations
NCT06468033 P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk · PharmaEssentia · Phase 3
2026-08-01
minor
Trial sites expanded: 36 → 39 locations
NCT06150157 A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated… · Janssen Research & Development, LLC · Phase 1
2026-08-01
minor
Trial sites expanded: 5 → 8 locations
NCT07469891 A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms · Prelude Therapeutics · Phase 1
2026-08-01
minor
Trial sites expanded: 222 → 225 locations
NCT05554406 Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed… · National Cancer Institute (NCI) · Phase 2
2026-08-20
minor
Completion pushed: 2026-06-30 → 2027-06-30
NCT02521493 Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or… · Children's Oncology Group · Phase 3

Active trials by phase

Early Phase 1
1
Phase 1
27
Phase 1/2
13
Phase 2
46
Phase 3
6
Not charted: 49 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 142

NCT IDTitleSponsorStatusUpdated
Phase 3
NCT04064060 A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other… Celgene Recruiting 2026-07-01
NCT05198960 AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic… University Hospital, Brest Recruiting 2026-03-20
NCT06740916 Long-term Efficacy of Once Daily Versus Twice Daily Aspirin in High-risk MPN Patients… Siriraj Hospital Recruiting 2024-12-27
NCT02521493 Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or… Children's Oncology Group Active, Not Recruiting 2026-08-19
NCT06468033 P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk PharmaEssentia Active, Not Recruiting 2026-08-13
NCT04717414 An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With… Celgene Active, Not Recruiting 2026-07-16
Phase 2
NCT05564390 MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study… National Cancer Institute (NCI) Recruiting 2026-08-27
NCT05554406 Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed… National Cancer Institute (NCI) Recruiting 2026-08-27
NCT04493164 CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or… M.D. Anderson Cancer Center Recruiting 2026-08-25
NCT06661915 A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative… National Cancer Institute (NCI) Recruiting 2026-08-19
NCT07228624 Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With… Fred Hutchinson Cancer Center Recruiting 2026-08-19
NCT07148947 Pacritinib With Standard of Care Azacitidine or Decitabine as a Bridge to Allogeneic… University of Washington Recruiting 2026-08-19
NCT02727803 Personalized NK Cell Therapy in CBT M.D. Anderson Cancer Center Recruiting 2026-07-30
NCT03779854 Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and… Fred Hutchinson Cancer Center Recruiting 2026-07-29
NCT06013423 Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in… Fred Hutchinson Cancer Center Recruiting 2026-07-22
NCT05805605 Allo HSCT Using RIC and PTCy for Hematological Diseases Masonic Cancer Center, University of Minnesota Recruiting 2026-07-06
NCT05074355 Study of Venetoclax and Azacitidine in Advanced BCR-ABL Negative Myeloproliferative… University Health Network, Toronto Recruiting 2026-07-06
NCT06815003 Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the… City of Hope Medical Center Recruiting 2026-06-29
NCT03314974 Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders Masonic Cancer Center, University of Minnesota Recruiting 2026-06-25
NCT03589729 Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in… M.D. Anderson Cancer Center Recruiting 2026-05-22
NCT05835466 Reparixin in Patients With Myelofibrosis Myeloproliferative Neoplasms Research Consortium… Icahn School of Medicine at Mount Sinai Recruiting 2026-05-06
NCT06599762 Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia University of Manitoba Recruiting 2026-04-22
NCT06063486 Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of… University of Southern California Recruiting 2026-03-27
NCT06859424 A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based… Center for International Blood and Marrow Transplant Research Recruiting 2026-03-17
NCT04282187 Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of… University of Washington Recruiting 2026-03-16

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