Disease landscape

Mantle Cell Lymphoma (MCL) clinical trials

Get alerts when Mantle Cell Lymphoma (MCL) trials change

39 active trials 25 recruiting 3 Phase 3 30 sponsors 5 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-07-31
notable
Recruitment opened
NCT07609862 A Study of Rocbrutinib in Combination With Lacutoclax in Patients With B-Cell Malignancies · Guangzhou Lupeng Pharmaceutical Company LTD. · Phase 1/2
2026-07-31
notable
Recruitment opened
Trial sites expanded: 2 → 6 locations
NCT07424833 A Study of APG-3288 in Relapsed/Refractory Blood Cancers · Ascentage Pharma Group Inc. · Phase 1
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06464861 Sequential Treatment of CD19 CARNK and 7x19 CAR-T in R/R B Cell Lymphoma · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 1
2026-08-14
minor
Trial sites expanded: 9 → 17 locations
NCT06980116 Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell… · Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc. · Phase 1

Active trials by phase

Phase 1
11
Phase 1/2
5
Phase 2
14
Phase 3
3
Phase 4
1
Not charted: 5 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 39

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07264894 ZSDT for the Treatment of R/R Mantle Cell Lymphoma After BTK Inhibitor Failure: a… Zhengzhou University Not Yet Recruiting 2025-12-04
Phase 3
NCT06496308 Bendamustine and Rituximab With or Without Orelabrutinib in MCL Treatment Ruijin Hospital Recruiting 2024-07-11
NCT07784101 A Phase 3 Study to Compare the Efficacy of ICP-248 in Combination With Orelabrutinib… Beijing InnoCare Pharma Tech Co., Ltd. Not Yet Recruiting 2026-08-25
NCT04662255 Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With… Loxo Oncology, Inc. Active, Not Recruiting 2026-05-15
Phase 2
NCT07272499 Orelabrutinib Plus Lisaftoclax and Rituximab in Untreated Mantle Cell Lymphoma With… Ruijin Hospital Recruiting 2026-07-28
NCT07082686 A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or… Beijing InnoCare Pharma Tech Co., Ltd. Recruiting 2026-07-23
NCT07719556 Orelabrutinib Combined With Obinutuzumab and Short-Course Venetoclax in Patients With… The First Affiliated Hospital with Nanjing Medical University Recruiting 2026-07-22
NCT04792489 DALY II USA/ MB-CART2019.1 for DLBCL Miltenyi Biomedicine GmbH Recruiting 2026-07-13
NCT07460362 Glofitamab Combined With Lenalidomide in High Risk Patients With Relapsed or Refractory… Peking University Third Hospital Recruiting 2026-03-10
NCT07077512 Relmacabtagene Autoleucel Combined With Sintilimab for Relapsed/Refractory B-cell Lymphoma Sun Yat-sen University Recruiting 2026-01-21
NCT07285590 Clinical Trial to Evaluate the Efficacy and Safety of Pirtobrutinib With Rituximab in… Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea Recruiting 2025-12-16
NCT07199296 Orelabrutinib and Rituximab With Optional Autologous Hematopoietic Stem Cell… Ruijin Hospital Recruiting 2025-09-30
NCT06846489 Acalabrutinib Plus Rituximab for the Treatment of Elderly or Low- to Intermediate-Risk… Sun Yat-sen University Recruiting 2025-06-03
NCT02213926 An Open-label, Phase 2 Study of ACP-196 (Acalabrutinib) in Subjects With Mantle Cell… Acerta Pharma BV Active, Not Recruiting 2026-08-04
NCT07684950 Lisaftoclax Plus Pirtobrutinib in Relapsed or Refractory Mantle Cell Lymphoma After… Henan Cancer Hospital Not Yet Recruiting 2026-07-06
NCT05951959 A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment… AstraZeneca Active, Not Recruiting 2026-06-01
NCT07569965 Frontline Risk-Adapted Optimization of Novel Targeted Immunotherapy Evaluation in… Miltenyi Biomedicine GmbH Not Yet Recruiting 2026-05-06
NCT05716087 A Study of Rocbrutinib in Participants With Relapse or Refractory Mantle Cell Lymphoma Guangzhou Lupeng Pharmaceutical Company LTD. Active, Not Recruiting 2026-01-15
Phase 1/2
NCT07788118 A Phase Ib/II Exploratory Clinical Trial of Memory-Enhanced 7×19-THEMIS CAR-T Cell… Second Affiliated Hospital, Zhejiang University, School of Medicine Recruiting 2026-08-26
NCT07609862 A Study of Rocbrutinib in Combination With Lacutoclax in Patients With B-Cell Malignancies Guangzhou Lupeng Pharmaceutical Company LTD. Recruiting 2026-07-30
NCT04186520 CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies Medical College of Wisconsin Recruiting 2026-02-23
NCT05471843 Study of BGB-11417 Monotherapy in Participants With Relapsed or Refractory Mantle Cell… BeiGene Active, Not Recruiting 2025-09-09
NCT03153202 Study to Evaluate the Safety and Preliminary Efficacy of Ibrutinib and Pembrolizumab in… Joshua Brody Active, Not Recruiting 2024-11-19
Phase 1
NCT06980116 Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell… Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc. Recruiting 2026-08-13
NCT07424833 A Study of APG-3288 in Relapsed/Refractory Blood Cancers Ascentage Pharma Group Inc. Recruiting 2026-07-30

Top sponsors by active trials in this area

Get alerts when Mantle Cell Lymphoma (MCL) trials change
Status changes, date slips, and new sponsor entrants: detected daily, delivered to your inbox.
Start monitoring free