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NCT07788118 · ClinicalTrials.gov record · last posted 2026-08-26

A Phase Ib/II Exploratory Clinical Trial of Memory-Enhanced 7×19-THEMIS CAR-T Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma

Name: A Phase Ib/II Exploratory Clinical Trial of Memory-Enhanced 7×19-THEMIS CAR-T Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma — clinical trial record (NCT07788118)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusRecruiting

PhasePhase 1/2

SponsorSecond Affiliated Hospital, Zhejiang University, School of Medicine

Started2026-09-01

View on ClinicalTrials.gov ↗

from the ClinicalTrials.gov record

This study is aimed to explored the safety and efficacy of 7×19-THEMIS CAR-T cell therapy for large B-cell lymphoma and to conduct an exploratory comparison of the 3-month objective response rate (ORR) and complete remission rate (CR rate) between the experimental cohort and the historical control cohort (NCT04833504).

Trial Details

NCT Number	NCT07788118
Lead Sponsor	Second Affiliated Hospital, Zhejiang University, School of Medicine
Conditions	Relapsed/Refractory Large B-cell Lymphoma (LBCL), Diffuse Large B-Cell Lymphoma (DLBCL), Primary Mediastinal Large B-cell Lymphoma (PMBCL), Transforming Follicular Lymphoma (tFL), Mantle Cell Lymphoma (MCL)
Enrollment	70 participants
Start Date	2026-09-01
Primary Completion	2029-09-01 (estimated)
Study Completion	2031-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-26