Disease landscape

ALK clinical trials

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535 active trials 272 recruiting 27 Phase 3 354 sponsors 66 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 41 of 66 changes on 20 trials

2026-08-22
critical
Primary completion pushed: 2026-04 → 2026-09
Primary endpoint(s) modified
Enrollment closed, study ongoing
Completion pushed: 2026-04 → 2026-10
NCT06817122 The "Let's Talk Tech" Tool to Support Decision Making About Technology Use · University of Washington
2026-08-22
critical
Primary completion pushed: 2026-08 → 2028-08
Completion pushed: 2026-12 → 2028-12
NCT07393971 Development of a Real-time Controller to Estimate Walking Performance Using a Bilateral… · University of Nebraska
2026-08-15
notable
Primary completion pushed: 2026-07-31 → 2026-12-31
Completion pushed: 2026-07-31 → 2026-12-31
NCT06400186 Movement Amplification Gait Training to Enhance Walking Balance Post-Stroke · VA Office of Research and Development
2026-08-20
notable
Primary completion pushed: 2026-02-28 → 2026-05-30
Trial completed
Completion pushed: 2026-02-28 → 2026-05-30
NCT04091464 TRAIN-BW: Backward Walking Training in Multiple Sclerosis · Wayne State University
2026-08-14
critical
Primary completion pushed: 2026-09 → 2027-09
Completion pushed: 2026-09 → 2027-09
NCT07287969 The Safety of Reusing Walking Boot Components for Patients Recovering From Acute Foot and… · University of Utah
2026-08-13
notable
Primary completion pushed: 2027-06 → 2027-12
Completion pushed: 2027-07 → 2028-01
NCT07540052 Impact of Loss Aversion Messaging and Anticipated Regret for Inaction on Exercise… · Milton S. Hershey Medical Center
2026-08-06
critical
Primary endpoint(s) modified
NCT07741994 Changes in Spatiotemporal Gait Parameters During a Digitally Assisted Self-rehabilitation… · University Hospital, Angers
2026-08-12
critical
Primary endpoint(s) modified
Primary completion pushed: 2028-11-30 → 2028-12-31
NCT07746375 Talking Circle for Native American Youth Living Well (AYoLi) · Melessa Kelley
2026-08-19
notable
Enrollment reduced: 40 → 34 participants
Trial completed
Primary completion moved earlier: 2026-10-01 → 2026-08-16
Completion moved earlier: 2026-10-01 → 2026-08-16
NCT07633093 Effects of a Powered Lower-Limb Exoskeleton on Walking Performance in Older Adults · Hunan Normal University
2026-08-05
critical
Enrollment reduced: 21110 → 8043 participants
Trial completed
Completion moved earlier: 2026-03-30 → 2026-02-16
NCT05006833 Text and Talk: A Multi-level Intervention to Increase Provider HPV Vaccine Recommendation… · University of Florida
2026-08-21
notable
Sponsor changed: Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair → Han Xu, M.D., Ph.D., FAPCR, Medical Director,, IRB Chair
Trial arms changed: 2 → 1
NCT05987956 Pharmacogenomics IND SNP Clinical Trial - Alectinib and Single Nucleotide Polymorphisms · Han Xu, M.D., Ph.D., FAPCR, Medical Director,, IRB Chair · Phase 2/3
2026-08-20
notable
Recruitment opened
Trial sites expanded: 0 → 5 locations
NCT07617337 AQUA07 in Patients With ALK-Positive Non-Small Cell Lung Cancer · Chugai Pharmaceutical · Phase 1
2026-08-15
notable
Enrollment closed, study ongoing
NCT04774718 A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric… · Hoffmann-La Roche · Phase 1/2
2026-08-07
notable
Trial completed
Primary completion moved earlier: 2026-05 → 2026-03-18
Completion moved earlier: 2026-05 → 2026-03-18
NCT07308418 The Influence of Vibrotactile Stimulation on Self-selected Walking Speed in People With… · Magnes AG
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07306052 Epidural Spinal Cord Stimulation for Restoring Walking in Spinal Cord Injury · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-20
notable
Trial completed
NCT02223208 Ro Plus CHOEP as First Line Treatment Before HSCT in Young Patients With Nodal Peripheral… · Fondazione Italiana Linfomi - ETS · Phase 1/2
2026-08-22
notable
Enrollment closed, study ongoing
NCT04231877 Polatuzumab Vedotin and Combination Chemotherapy With or Without Glofitamab for the… · University of Washington · Phase 1
2026-08-22
notable
Enrollment closed, study ongoing
NCT07006818 Impaired Interlimb Coordination During Locomotion in Individuals With Chronic Stroke… · University of Illinois at Chicago
2026-08-21
notable
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Completion pushed: 2026-06-30 → 2026-08-30
NCT07272070 The Effect of Home-Based Walking on Symptoms and Health Profile of Hemodialysis Patients · Figen Akay
2026-08-21
notable
Trial completed
Enrollment increased: 46 → 53 participants
NCT04573530 We Walk Plus Study for Older Adults With Intellectual Disabilities · University of Illinois at Chicago

Active trials by phase

Early Phase 1
6
Phase 1
21
Phase 1/2
22
Phase 2
67
Phase 2/3
6
Phase 3
21
Phase 4
10
Not charted: 382 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 535

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05761015 Helping Osteoarthritis Patients to Walk With NSAID University Hospital, Clermont-Ferrand Recruiting 2026-02-27
NCT05005793 Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients University of Colorado, Denver Recruiting 2025-05-29
NCT04957329 Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on… Rigshospitalet, Denmark Recruiting 2023-11-18
NCT07674368 Rucaparib Monoclonal Antibody for Lorlatinib-Induced Hypercholesterolemia / Mixed Hunan Cancer Hospital Not Yet Recruiting 2026-07-01
NCT07671560 Efficacy and Safety of Ensartinib Combined With Anlotinib in Lorlatinib-Resistant… Qiming Wang Not Yet Recruiting 2026-06-26
NCT02584933 Roll-over Study to Allow Access to Certinib (LDK378) for Patients Who Are on Ceritinib… Novartis Pharmaceuticals Active, Not Recruiting 2026-06-11
NCT06282874 Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases Guangdong Association of Clinical Trials Active, Not Recruiting 2026-04-09
NCT06893354 Explore the Mechanisms Underlying Disease Resistance and Potential Primary Resistance… The First Affiliated Hospital of Guangzhou Medical University Not Yet Recruiting 2025-03-25
NCT06785584 Efficacy and Safety of Ensartinib in Neoadjuvant Therapy for Stage IIA - IIIB (Operable… Fujian Medical University Union Hospital Not Yet Recruiting 2025-01-21
NCT03888820 Biofreeze® vs. a Placebo on Chronic Low Back Pain Walking Gait Characteristics and Pain Sport and Spine Rehab Clinical Research Foundation Active, Not Recruiting 2019-03-25
Phase 3
NCT07419334 Study of ALK-001 on the Progression of Stargardt Disease Alkeus Pharmaceuticals, Inc. Recruiting 2026-08-26
NCT06765109 Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC Nuvalent Inc. Recruiting 2026-08-25
NCT06724237 Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells… Eastern Cooperative Oncology Group Recruiting 2026-08-19
NCT07455383 A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1 Alkermes, Inc. Recruiting 2026-08-07
NCT07502443 A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2 Alkermes, Inc. Recruiting 2026-08-07
NCT07540897 A Study to Evaluate the Efficacy, Safety and Tolerability of ALKS 2680 in Adults With… Alkermes, Inc. Recruiting 2026-08-07
NCT06032065 SMART Exercise for PAD Northwestern University Recruiting 2026-04-15
NCT06760546 A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of… Rhythm Pharmaceuticals, Inc. Recruiting 2026-02-12
NCT05991908 Randomized Study of Conditioning of Fludarabine Combined With Single or Dual Alkylating… Shanghai Jiao Tong University School of Medicine Recruiting 2025-02-18
NCT06643416 Efficacy and Safety of Add-on Timolol for EGFR-TKI and ALK-TKI Induced Paronychia Queen Mary Hospital, Hong Kong Recruiting 2024-10-18
NCT06623123 Oto Smartphone App in Treating Tinnitus Amongst Adult Patients Compared with Standard… East and North Hertfordshire NHS Trust Recruiting 2024-10-02
NCT05341583 Ensartinib as Adjuvant Treatment in Anaplastic Lymphoma Kinase (ALK) Positive Non-small… Betta Pharmaceuticals Co., Ltd. Recruiting 2024-08-23
NCT03456076 A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in… Hoffmann-La Roche Active, Not Recruiting 2026-07-15
NCT07645248 A Study to Compare Safety of 4 Weeks Exposure to Propellants Hydrofluoroalkane… GlaxoSmithKline Not Yet Recruiting 2026-06-12
NCT02201992 Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has… ECOG-ACRIN Cancer Research Group Active, Not Recruiting 2025-12-19

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