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NCT04091464 · ClinicalTrials.gov record · last posted 2026-08-19

TRAIN-BW: Backward Walking Training in Multiple Sclerosis

Study acronym: TRAIN-BW
StatusCompleted
PhaseNot applicable
Started2020-01-01
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from the ClinicalTrials.gov record
Individuals with multiple sclerosis (MS) experience in impairments in mobility and cognition that increase the risk for accidental falls. More than 50% of individuals with MS experience injurious falls within a 6-month period. Current interventions to improve fall risk have focused on forward walking (FW) and balance training, resulting in small declines in the relative risk for falls with a large degree of variability. Interestingly, motor differences between MS and healthy controls are more pronounced in backward walking (BW), yet no studies have investigated BW training as an intervention to reduce fall risk in persons with MS. This study will investigate the feasibility, acceptability and impact of BW training compared to forward walking training on motor function and fall risk in persons with MS.

Protocol amendment history 3 changes detected by DataLookout

2026-08-20
notable
Trial completed
2026-08-20
notable
Primary completion pushed: 2026-02-28 → 2026-05-30
2026-08-20
minor
Completion pushed: 2026-02-28 → 2026-05-30
Trial Details
NCT Number NCT04091464
Lead Sponsor Wayne State University
Conditions Multiple Sclerosis, Gait Disorders, Neurologic, Accidental Fall
Enrollment 90 participants
Start Date 2020-01-01
Primary Completion 2026-05-30 (estimated)
Study Completion 2026-05-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-19