Comprehensive Clinical Prediction Rule for Acute Heart Failure

The goal of this prospective observational cohort study is to establish a comprehensive clinical prediction rule integrating clinical characteristics, point-of-care testing (POCT) of NT-proBNP, an 8-point LUS, and a rapid cardiac assessment using bedside echocardiography for diagnosing acute heart failure (AHF) in the emergency department. A clinical prediction rule with high diagnostic accuracy will minimize delays and misdiagnoses, as well as the potential harm they may cause to patients. The primary outcome measure is the adjudicated AHF diagnosis. Secondary outcome measures include ED and discharge diagnosis of the patients.

NCT Number	NCT07754084
Lead Sponsor	Chinese University of Hong Kong Collaborators: Prince of Wales Hospital, Shatin, Hong Kong, The University of Hong Kong, Tuen Mun Hospital, Hospital Authority, Hong Koong, Queen Mary Hospital, Hong Kong
Conditions	Acute Heart Failure (AHF)
Enrollment	560 participants
Start Date	2026-08-17
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-01-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-11