Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation

People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample. Newer guidelines recommend repeating the test after 1 hour instead, which may allow patients to receive a diagnosis and leave the hospital sooner. The purpose of the DanRUSH trial is to compare these two strategies: repeating the blood test after 1 hour versus after 3 hours in adults with suspected acute coronary syndrome. The study will evaluate whether the 1-hour strategy is as safe as the 3-hour strategy while reducing the length of hospital stay. DanRUSH is a nationwide, pragmatic, cluster-randomized trial conducted in emergency- and cardiology departments across Denmark. The results will help determine the best timing for blood testing in patients with suspected heart attack and improve future care for these patients.

NCT Number	NCT07727135
Lead Sponsor	Herlev and Gentofte Hospital Collaborators: Bispeberg and Frederiksberg Hospital, Hvidovre and Amager Hospital, North Zealand (Hillerød) Hospital, Nykøbing Falster Sygehus, Gødstrup Hospital, Regionshospitalet Viborg, Skive, Odense Universitetshospital, Esbjerg sygehus, Aalborg University Hospital
Conditions	Coronary Syndrome, Acute, Myocardial Infarction, Coronary Artery Disease, Cardiovascular Diseases, Cardiovascular Disease Acute
Enrollment	28,000 participants
Start Date	2026-09-01
Primary Completion	2028-09-01 (estimated)
Study Completion	2029-02-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-06