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Polypills Approach for Multiple Cardiovascular Risk Factors

Study acronym: PACIF
StatusRecruiting
PhaseNot applicable
Started2026-07-11
View on ClinicalTrials.gov ↗

Amendment history

2026-09-17
Recruitment opened
Trial sites expanded: 12 → 15 locations
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for the integrated management of hypertension, dyslipidemia, and type 2 diabetes among adults aged 50 to 75 years without prior cardiovascular disease in China. The trial will evaluate whether a fixed-dose combination strategy improves the 10-year cardiovascular disease risk estimated using the PREVENT equations at Phase 1. Participants will be further followed to determine whether the fixed-dose combination strategy reduces major cardiovascular events and improves cognitive outcomes compared with usual care at Phase 2.
Trial Details
NCT Number NCT07679828
Lead Sponsor China Medical University, China
Conditions Hypertension, Dyslipidemia, Diabetes
Enrollment 8,252 participants
Start Date 2026-07-11
Primary Completion 2029-12-31 (estimated)
Study Completion 2030-03-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-16