Exercise and Intranasal Insulin in Type 2 Diabetes

About 6.5 million adults in the United States who are 65 or older have dementia. While the exact cause of dementia is not known, it may be due to changes in the brain. Further, risk may be higher when the brain does not respond to insulin. Indeed, brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control. Regular aerobic exercise may help reduce the risk of dementia by increased blood flow to the brain and help the brain respond better to insulin. In addition, giving insulin through a nose spray (called intranasal insulin) may also help with thinking and memory. However, it is unknown if using both exercise and intranasal insulin is best for the brain.

NCT Number	NCT07675499
Lead Sponsor	Rutgers, The State University of New Jersey Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions	Type 2 Diabetes, Insulin Sensitivity/Resistance, Cognition, Brain Blood Flow
Enrollment	60 participants
Start Date	2026-08-03
Primary Completion	2029-05-18 (estimated)
Study Completion	2029-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-30