Clinical Trial

Adjunctive Resonance-Based Chinese Five-Element Music Intervention for Depressive Disorders and Anxiety Symptoms in Male Inpatients

Study acronym: RCFMI
Enrolling by Invitation
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Record status
This record was last updated June 17, 2026 (before its estimated July 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
This randomized controlled trial will evaluate the effectiveness of Resonance-Based Chinese Five-Element Music Intervention (RFEMI) as an adjunct to pharmacotherapy in male inpatients with depressive disorders. Based on Traditional Chinese Medicine Five-Element tone theory and resonance-informed acoustic delivery, RFEMI will be compared with conventional music intervention plus pharmacotherapy and pharmacotherapy alone over a four-week intervention period. The study will assess changes in depressive and anxiety symptoms, TCM syndrome characteristics, neuroendocrine biomarkers, cerebral oxygenation, and autonomic nervous system regulation.
Trial Details
NCT Number NCT07653113
Lead Sponsor University of Malaya
Conditions Depressive Disorder, Anxiety, Randomised Controlled Trial
Enrollment 100 participants
Start Date 2026-06-05
Primary Completion 2026-07-30 (estimated)
Study Completion 2026-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-06-17