Dry Weight Reduction Intervention Via Extra Ultrafiltration

Most patients who receive hemodialysis treatments have excess fluid in their body that has slowly built up over the course of kidney disease. This extra fluid is the main cause of high blood pressure in dialysis and leads to stress on the heart and lungs.that causes debilitating symptoms and frequent hospitalizations. This trial will test whether a focused program of 4 or 8 weeks of extra ultrafiltration treatments can remove most of this extra fluid. We believe that getting rid of large amounts of extra fluid will result in sustained improvements in blood pressure and symptoms. Ultrafiltration is a gentler type of dialysis that removes fluid but does not clean the blood.

NCT Number	NCT07637110
Lead Sponsor	University of Washington Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions	Fluid Accumulation, Blood Pressure Management, End Stage Renal Disease (ESRD)
Enrollment	120 participants
Start Date	2026-06
Primary Completion	2030-02 (estimated)
Study Completion	2030-11 (estimated)
Updated on ClinicalTrials.gov	2026-06-09