Gut Oxygen Therapy for Ischemic-Hypoxic Bowel Disease

This single-center, double-blind, randomized, intra-individual crossover controlled study aims to investigate the efficacy and safety of intestinal oxygen therapy via a deep intestinal catheter as a targeted route for intestinal oxygen delivery in the treatment of ischemic-hypoxic enteropathy, and simultaneously to explore and verify the chronobiological differences. Data have been obtained from the study based on the first version of our pilot study. Considering ethics and cost-effectiveness, a new protocol needs to be designed to achieve the research goals with minimal intervention, minimal cost, and the smallest sample size.

NCT Number	NCT07621367
Lead Sponsor	The Second Hospital of Nanjing Medical University
Conditions	Chronic Ischemic-Hypoxic Enteropathy
Enrollment	100 participants
Start Date	2026-08-02
Primary Completion	2031-04-19 (estimated)
Study Completion	2031-05-19 (estimated)
Updated on ClinicalTrials.gov	2026-08-05