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Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

Study acronym: TNT Esophagus
StatusRecruiting
PhasePhase 2
Started2026-09
View on ClinicalTrials.gov ↗

Amendment history

2026-09-30
Recruitment opened
2026-08-26
Study Status, Contacts/Locations v2
Start date2026-08-01→2026-09
Study sitescontacts updated at 1 of 1 site
2026-05-27
Study Status, Arms and Interventions, Eligibility v1
Eligibility criteria+112 characters
[...] in 21 days of signing consent; Staging whole-body FDG-PET/CT (fluorodeoxyglucose-positron emission tomography/computed tomography) scan with or without contrast (preferred) or chest/abdominal (CT [...] ase must be obtained within 45 days of study enrollment ECOG (Eastern Cooperative Oncology Group) performance status of 0-2 Subjects must be appropriate cand [...]
2026-05-18
Original filing
The goal of this trial is to learn if adding consolidative chemotherapy to routine chemoradiation can better control both local recurrence and metastasis and reduce the need for surgical intervention.
Trial Details
NCT Number NCT07603375
Lead Sponsor Duke University
Conditions Esophageal Adenocarcinoma
Enrollment 60 participants
Start Date 2026-09
Primary Completion 2029-08-01 (estimated)
Study Completion 2034-02 (estimated)
Updated on ClinicalTrials.gov 2026-09-29