Clinical Trial

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

Study acronym: TNT Esophagus
Not Yet Recruiting Phase 2
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Summary
The goal of this trial is to learn if adding consolidative chemotherapy to routine chemoradiation can better control both local recurrence and metastasis and reduce the need for surgical intervention.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-05-18.
Trial Details
NCT Number NCT07603375
Lead Sponsor Duke University
Conditions Esophageal Adenocarcinoma
Enrollment 60 participants
Start Date 2026-08-01
Primary Completion 2029-08-01 (estimated)
Study Completion 2034-02 (estimated)
Updated on ClinicalTrials.gov 2026-05-29