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Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure

Study acronym: CLORINA-IC
StatusRecruiting
PhaseNot specified
Started
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Record History

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  1. Recruitment opened Show 5 more changesShow less
    • Start date changed from estimate of May 2026 to May 6, 2026
    • Eligibility criteria expanded, about 17 words
    • Secondary endpoints: details revised at 2 of 6 entries
    • Site details revised at 4 of 4 sites
    • Publications: details revised at 1 of 1 entry
  2. Eligibility criteria shortened, about 17 words
    • Secondary endpoints: details revised at 4 of 6 entries
    • Study description revised
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this observational study is to learn how changes in urinary sodium and chloride levels relate to fluid overload and short-term outcomes in patients hospitalized with acute heart failure (AHF). The main questions it aims to answer are: * Do changes over time in urinary sodium and chloride reflect how well excess fluid is being removed during hospitalization? * Are these changes associated with residual congestion at discharge and with the risk of worsening heart failure or death after discharge? Participants hospitalized for AHF and treated with intravenous diuretics as part of their usual care will have clinical assessments, blood and urine tests, and echocardiographic evaluations collected at several time points during their hospital stay. Researchers will also record clinical outcomes, including worsening heart failure or death, at 30 days and 3 months after discharge.
Trial Details
NCT Number NCT07597512
Lead Sponsor Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Collaborators: Carlos III Health Institute
Conditions
(from sponsor)		 Acute Heart Failure (AHF), Heart Failure, Congestion
Related terms Heart Failure
Enrollment 223 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov