Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection Fraction

Heart failure with reduced ejection fraction (HFrEF) is frequently associated with abnormalities in body composition, including reduced skeletal muscle mass and sarcopenia, which are independent predictors of reduced exercise tolerance, impaired quality of life, and increased mortality. Despite advances in pharmacological therapy, evidence-based non-pharmacological strategies aimed at preventing muscle mass loss remain limited. This randomized controlled trial aims to evaluate the effects of dietary intervention based on the DASH diet with high-protein elements, resistance exercise training, and their combination on skeletal muscle mass, functional capacity, echocardiographic parameters, biochemical markers, and quality of life in patients with HFrEF.

NCT Number	NCT07595809
Lead Sponsor	Medical University of Silesia
Conditions	Heart Failure With Reduced Ejection Fraction
Enrollment	100 participants
Start Date	2023-05-08
Primary Completion	2026-07-31 (estimated)
Study Completion	2027-04 (estimated)
Updated on ClinicalTrials.gov	2026-05-19