Ultrasonic Debris Clearance to Promote Brain Resilience

This pilot study will evaluate the safety, tolerability, and feasibility of Ultrasonic Debris Clearance (UDC), a noninvasive low-intensity focused ultrasound intervention, in amyloid-positive adults who are asymptomatic but at risk for Alzheimer's disease, or who have mild cognitive impairment or mild dementia. The study is designed to test whether repeated UDC sessions can be delivered safely and feasibly in this population, while also exploring efficacy via biomarkers and clinical measures.

NCT Number	NCT07573982
Lead Sponsor	Stanford University
Conditions	Alzheimer s Disease, MCI With Increased Risk for Alzheimer Disease
Enrollment	15 participants
Start Date	2026-07
Primary Completion	2027-07 (estimated)
Study Completion	2027-07 (estimated)
Updated on ClinicalTrials.gov	2026-05-07