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Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Atrasentan in Pediatric Patients With Primary IgAN

Study acronym: ADVANCE
StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Minor Trial sites expanded: 9 → 12 locations Start date changed from estimate of Aug 26, 2026 to Aug 6, 2026 · Eligibility criteria expanded, about 40 words · Secondary endpoints: details revised at 1 of 6 entries · 2 more Show 5 more changesShow less
    • Start date changed from estimate of Aug 26, 2026 to Aug 6, 2026
    • Eligibility criteria expanded, about 40 words
    • Secondary endpoints: details revised at 1 of 6 entries
    • Study description revised
    • Publications: details revised at 1 of 1 entry
  2. Minor Trial sites expanded: 6 → 9 locationsv7
  3. Notable Recruitment opened Trial sites expanded: 2 → 6 locationsv6 Show 1 more changeShow less
    • Trial sites expanded: 2 → 6 locations
  4. Minor Re-verified, no change to tracked fieldsv5
  5. Minor Study sites: 0 to 2v4
  6. Notable Primary completion pushed from Nov 29, 2030 to Sep 15, 2031 Completion pushed from Jan 31, 2031 to Dec 13, 2032 · Start date: Oct 2, 2026 to Aug 26, 2026v3 Show 2 more changesShow less
    • Completion pushed from Jan 31, 2031 to Dec 13, 2032
    • Start date: Oct 2, 2026 to Aug 26, 2026
  7. Minor Publications: details revised at 1 of 1 entryv2
  8. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
555 trials monitored
See 31 trials at risk
A Phase III, single-arm, multicenter pediatric clinical study evaluating atrasentan in children and adolescents aged 2 to \<18 years with primary immunoglobulin A nephropathy (IgAN).
Trial Details
NCT Number NCT07498335
Lead Sponsor Novartis Pharmaceuticals
Conditions Berger Disease, Bergers Disease, IgA Nephropathy, Immunoglobulin A Nephropathy, Primary IgAN, Nephritis IgA Type, Nephropathy IgA Type
Enrollment 28 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov