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Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance

StatusRecruiting
PhasePhase 4
Started
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Record History

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  1. Recruitment opened Show 4 more changesShow less
    • Start date changed from estimate of Jul 1, 2026 to Jul 16, 2026
    • Eligibility criteria expanded, about 20 words
    • Secondary endpoints: details revised at 3 of 4 entries
    • Site details revised
  2. Primary endpoint(s) modifiedv2 Show 5 more changesShow less
    • Enrollment increased: 24 → 48 participants
    • Start date: May 1, 2026 to Jul 1, 2026
    • Trial arms changed: 2 → 4
    • Secondary endpoints revised (4)
    • Study description shortened, about 3 words
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction. Chronic sleep loss is highly prevalent, affecting 1 in 3 adults in the US. Chronic sleep loss causes stress which induces insulin resistance and leads to obesity and type 2 diabetes. Many factors contribute to sleep loss including shift work, environmental disturbances, sleep/circadian disorders and comorbid medical and mental health conditions. Sleep loss increases the stress hormone cortisol in the evening and decreases daytime testosterone. Examining these hormones in a controlled laboratory environment under different sleep schedules may help researchers find solutions for adults experiencing negative health consequences related to chronic sleep loss.
Trial Details
NCT Number NCT07494084
Lead Sponsor Washington State University
Collaborators: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Conditions
(from sponsor)		 Shift Work Schedule, Circadian Rhythm, Insulin Resistance, Circadian Misalignment
Related terms Diabetes Mellitus, Type 2, Insulin Resistance
Enrollment 48 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov