Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and Cardiovascular Risk in Women With Type 1 Diabetes

This multicenter observational cohort study aims to evaluate whether estimated first-trimester risk of preeclampsia (PE) is associated with subclinical atherosclerosis, cardiovascular risk profile, and cardiovascular events in women with type 1 diabetes (T1D) at least 3 years after pregnancy. Women with T1D and at least one prior pregnancy with documented first-trimester PE screening will be classified as high or low PE risk according to validated multivariable algorithms. The presence of carotid plaques, cardiometabolic risk factors, and incident cardiovascular events will be assessed during a study visit.

NCT Number	NCT07479329
Lead Sponsor	Institut d'Investigacions Biomèdiques August Pi i Sunyer Collaborators: Hospital Mutua de Terrassa, Sociedad Española de Endocrinología y Nutrición
Conditions	Type 1 Diabetes, Preeclampsia, Preeclampsia (PE) Risk
Enrollment	1,300 participants
Start Date	2026-04-10
Primary Completion	2028-04-30 (estimated)
Study Completion	2028-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-18