The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

StatusCompleted
PhaseNot applicable
Started

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Record History

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  1. Trial completed Show 8 more changesShow less
    • Primary completion date changed from estimate of Nov 2026 to Sep 30, 2026
    • Start date changed from estimate of May 1, 2026 to Mar 23, 2026
    • Interventions: Placebo Supplementation (Drug), Pyridoxal-5'-Phosphate supplement (Drug) to Placebo Supplementation (Drug), Pyridoxal-5'-Phosphate supplement (Drug)
    • Eligibility criteria expanded, about 10 words
    • Site details revised
    • Collaborator revised
    • Publications: details revised at 1 of 1 entry
    • Study description expanded, about 3 words
  2. Start date: Feb 2026 to May 1, 2026v3
  3. Eligibility criteria shortened, about 102 words
    • Collaborator revised
    v2
  4. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
University of Reading
32 trials monitored
See 1 trial at risk
Anxiety
3,284 trials monitored
See 154 trials at risk
Depression
3,069 trials monitored
See 170 trials at risk
This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.
Trial Details
NCT Number NCT07469462
Lead Sponsor University of Reading
Collaborators: INNOPURE
Conditions
(from sponsor)		 Neural Inhibition, Anxiety, Depression
Related terms Anxiety Disorders, Depression
Enrollment 44 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov