Metaverse Applications in Clinical Neurorehabiliation: Device Feasibility

The main objective of the TERSICORE project is the development of a new advanced set of exergames in the Metaverse that can be used in all clinical and home rehabilitation devices to improve the cognitive therapy of neurological patients by exploiting the potential of social rehabilitation. Five specific exargames will be developed: a) Cooking therapy (Coordinating in a kitchen to complete a dish through shared activities); b) Escape Room (Exiting a simulated room by solving problems and logic puzzles); c) Nostalgia Bits (Sharing personal reminiscence narratives within simulated spaces); d) NeuroTeam (Mindfulness); and e) Truman Show Exploration of an urban space and role-playing. All exargames will be validated on a small population of neurological patients according to cognitive profile.

NCT Number	NCT07456475
Lead Sponsor	Istituto per la Ricerca e l'Innovazione Biomedica Collaborators: H.S.P.I. s.p.a., Catholic University of the Sacred Heart, Fondazione Don Carlo Gnocchi ETS
Conditions	Neurological Disorder, Multiple Sclerosis, Parkinson Disease, Stroke, Traumatic Brain Injury
Enrollment	25 participants
Start Date	2025-06-06
Primary Completion	2027-04-01 (estimated)
Study Completion	2027-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-06