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A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)

StatusCompleted
PhasePhase 1
Started
View on ClinicalTrials.gov ↗

Record History

  1. Lead sponsor: Merck Sharp & Dohme LLC to Merck Sharp & Dohme LLC Trial completed · Enrollment target: estimated 120 to confirmed 122 · Study sites: 5 to 4 · 4 more Show 7 more changesShow less
    • Trial completed
    • Enrollment target: estimated 120 to confirmed 122
    • Study sites: 5 to 4
    • Primary completion date changed from estimate of Sep 2, 2026 to Sep 1, 2026
    • Study completion date changed from estimate of Sep 9, 2026 to Sep 10, 2026
    • Secondary endpoints: details revised at 3 of 11 entries
    • Eligibility criteria expanded, about 4 words
  2. Primary completion date: Aug 19, 2026 to Sep 2, 2026 Completion date: Aug 19, 2026 to Sep 9, 2026v8 Show 1 more changeShow less
    • Completion date: Aug 19, 2026 to Sep 9, 2026
  3. Trial status changed: Recruiting → Active, Not Recruiting Site details revised at 5 of 5 sitesv7 Show 1 more changeShow less
    • Site details revised at 5 of 5 sites
  4. Site details revised at 1 of 5 sitesv6
  5. Study sites: 4 to 5v5
Show 3 earlier versionsHide 3 earlier versions
  1. Study sites: 2 to 4v4
  2. Study sites: 1 to 2 Start date changed from estimate of Feb 27, 2026 to Mar 4, 2026v3 Show 1 more changeShow less
    • Start date changed from estimate of Feb 27, 2026 to Mar 4, 2026
  3. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 1v2 Show 1 more changeShow less
    • Study sites: 0 to 1
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Merck (MSD)
407 trials monitored
See 29 trials at risk
Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies. The goals of this study are to learn about: * The safety of MK-4082 and if people tolerate it * What happens to different MK-4082 dose levels in a person's body over time
Trial Details
NCT Number NCT07388667
Lead Sponsor Merck Sharp & Dohme LLC
Conditions Healthy
Enrollment 122 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov