Clinical Trial

Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure

Study acronym: SAND-HF
Recruiting
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Summary
Heart failure is a chronic condition that causes congestion and frequent hospitalizations. Diuretic doses are usually adjusted based on clinical judgment without an objective measure of response. This study will test the feasibility of using point-of-care urine sodium measurements to guide up-titration or down-titration of loop diuretics in ambulatory patients with heart failure. Participants will be assigned to one of three groups based on congestion status. Groups 1 and 2 will be randomized 1:1 to natriuresis-guided therapy or standard care. Group 3 will be observational. The 90-day pilot trial will evaluate feasibility, clinical outcomes, and usability of a urine sodium-guided titration strategy.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-01-18.
Trial Details
NCT Number NCT07369856
Lead Sponsor Cardiology Research UBC
Conditions Heart Failure, Diuretics
Enrollment 300 participants
Start Date 2025-11-04
Primary Completion 2027-05-31 (estimated)
Study Completion 2027-12-30 (estimated)
Updated on ClinicalTrials.gov 2026-03-27