Efficacy and Safety of Probiotics for Anxiety Depression

This randomized, double-blind, placebo-controlled study will enroll 60 individuals with mild-to-moderate anxiety depression. Following a 3-month intervention and a 1-month follow-up period, the study aims to: 1) evaluate the efficacy of probiotics by comparing anxiety, depression, and sleep scores to baseline; and 2) investigate the safety and underlying mechanisms by analyzing changes in serum biomarkers, gut microbiota, and related metabolites.

NCT Number	NCT07331987
Lead Sponsor	Moon (Guangzhou) Biotechnology Co., Ltd.
Conditions	Anxiety Depression
Enrollment	60 participants
Start Date	2026-06-15
Primary Completion	2026-12-30 (estimated)
Study Completion	2027-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-06-29