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Remotely-supervised Neuromodulation in PPA

StatusRecruiting
PhaseNot applicable
SponsorMaya Henry
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 10 months later May 2029 → Apr 1, 2030
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Record History

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  1. Notable Primary completion pushed from May 2029 to Apr 1, 2030
    • Study completion pushed from Aug 2029 to Apr 30, 2030
    v6
  2. Minor Eligibility criteria revisedv5
  3. Minor Re-verified, no change to tracked fieldsv4
  4. Notable Lead sponsor: University of Texas at Austin to Maya Henry
    • Start date: Jan 2026 to Apr 15, 2026
    • Interventions: Lexical Retrieval Cascade Treatment (Behavioral), Remotely Supervised Transcranial Direct Current Stimulation (Device) to Lexical Retrieval Cascade Treatment (Behavioral), Remotely Supervised Transcranial Direct Current Stimulation - Sham (Device), Remotely…
    • Eligibility criteria expanded, about 7 words
    v3
  5. Notable Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 1 to 2
    v2
  6. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
2 trials monitored
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1,978 trials monitored
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The goal of this clinical trial is to learn whether home-based brain stimulation combined with virtual speech-language therapy can improve communication abilities in adults with logopenic variant primary progressive aphasia (lvPPA), a language disorder most often caused by Alzheimer's disease. The main questions the study aims to answer are: * Is combining remotely supervised transcranial direct current stimulation (tDCS) with virtual speech-language therapy feasible and acceptable for people with lvPPA? * Does this combined treatment lead to improvements in communication compared to speech-language therapy with sham (placebo) stimulation? * Do individual brain characteristics help predict who benefits most from this treatment? Researchers will compare participants who receive active tDCS plus virtual speech-language therapy to participants who receive sham (placebo) tDCS plus virtual speech-language therapy to see if active brain stimulation enhances communication outcomes. Participants will: * Complete speech-language therapy sessions delivered by video visit. * Receive either active or sham tDCS that is remotely supervised and completed at home. * Complete language and cognitive testing before and after treatment. * Undergo brain imaging and other assessments to help understand treatment response.
Trial Details
NCT Number NCT07260253
Lead Sponsor Maya Henry
Collaborators: National Institute on Aging (NIA)
Conditions
(from sponsor)
Primary Progressive Aphasia(PPA), Progressive Aphasia, Progressive Aphasia in Alzheimer's Disease, Logopenic Progressive Aphasia (LPA), Logopenic Variant Primary Progressive Aphasia, Logopenic Variant of Primary Progressive Aphasia (LPA)
Related terms Aphasia, Aphasia, Primary Progressive, Communication Disorders
Enrollment 80 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov