[18F]FT8 PET Imaging in Immunoglobulin Light Chain Amyloidosis

\[18F\]FT8, a derivative of 1-(4-pyridyl)-4-piperazinyl arene (\[18F\]TPZA), exhibits high affinity for AL amyloid in myocardial tissue sections and shows no significant binding to transthyretin amyloid. By comparing its diagnostic performance against established clinical methods, including echocardiography, contrast-enhanced MRI, and relevant laboratory tests, this study aims to establish \[18F\]FT8 as the basis for a robust PET protocol for the direct visualization and differential diagnosis of AL amyloidosis . The study preimarily evaluates the safety and diagnostic efficacy of \[18F\]FT8 PET imaging in human subjects.

NCT Number	NCT07232459
Lead Sponsor	Tianjin Medical University Collaborators: Tianjin Medical University General Hospital
Conditions	Amyloid, Cardiac Amyloidosis, Amyloidosis, Healthy Subjects
Enrollment	25 participants
Start Date	2025-07-21
Primary Completion	2028-07-20 (estimated)
Study Completion	2028-12-20 (estimated)
Updated on ClinicalTrials.gov	2025-11-18