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Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

Name: Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy — clinical trial record (NCT07226765)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: MARITIME-OSA-2

StatusRecruiting

PhasePhase 3

SponsorAmgen

Started2025-11-25

View on ClinicalTrials.gov ↗

This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with obstructive sleep apnea (OSA) who are not on PAP therapy and are living with overweight or obesity.

Amendment history 7 changes detected by DataLookout

2026-08-15

Trial sites expanded: 54 → 57 locations

2026-06-05

Trial sites expanded: 49 → 53 locations

2026-05-23

Trial sites expanded: 46 → 49 locations

2026-05-15

Trial sites expanded: 42 → 46 locations

2026-05-06

Trial sites expanded: 38 → 42 locations

2026-04-25

Trial sites expanded: 34 → 38 locations

2026-04-10

Trial sites expanded: 28 → 32 locations

Trial Details

NCT Number	NCT07226765
Lead Sponsor	Amgen
Conditions	Obstructive Sleep Apnea
Enrollment	250 participants
Start Date	2025-11-25
Primary Completion	2027-09-29 (estimated)
Study Completion	2028-09-13 (estimated)
Updated on ClinicalTrials.gov	2026-08-14