Mental Health Mission Mood Disorder Cohort Study

The current study aims to understand why some people with depression respond to treatment and others do not, using markers of clinical symptoms, both clinician reported outcome measures and patient reported outcome measures, demographic information, cognitive function, genetic sequence information (genomic), chemical measures of metabolism (metabolomic), protein makeup (proteomic) and the body's natural defence system (immune/inflammatory markers) together with collections of cells that will facilitate new research to drive improvements in diagnosis and treatment of mood disorders that may be proving difficult to treat. This will allow future clinical trials within the NHS, academia and industry to drive forward new approaches and treatments. Participants who provide consent for re-contact for future treatment trials and other research studies have the potential to benefit from this with participation in experimental studies and clinical trials associated with improved patient outcomes. Overall, the cohort will generally support greater access to research opportunities for a wider population of people.

NCT Number	NCT07189689
Lead Sponsor	University of Oxford Collaborators: Newcastle University, University of Nottingham, University of Exeter, University of Southampton, University of Birmingham, University of Manchester, University of Liverpool, Avon and Wiltshire Mental Health Partnership NHS Trust, Cambridgeshire and Peterborough NHS Foundation Trust, University of Cambridge, Cardiff University, Cardiff and Vale University Health Board, University of Edinburgh, University of Glasgow, University College, London, Sheffield Health and Social Care NHS Foundation Trust, King's College London, Imperial College London, Oxford Health NHS FT, Cumbria, Northumberland, Tyne and Wear NHS FT, South London and Maudsley NHS FT, Nottinghamshire Healthcare NHS FT, Devon Partnership Trust, Hampshire and Isle of Wight Health NHS FT, Birmingham and Solihull Mental Health NHS Trust, Mersey Care NHS FT, NHS Lothian, NHS Greater Glasgow & Clyde, Camden & Islington NHS FT, West London NHS FT, Central and North West London NHS FT
Conditions	Depression - Major Depressive Disorder, Depression Bipolar, Treatment Resistant Depression
Enrollment	2,000 participants
Start Date	2025-10-01
Primary Completion	2028-01-31 (estimated)
Study Completion	2028-01-31 (estimated)
Updated on ClinicalTrials.gov	2025-10-03