Clinical Trial

Multicentre Longitudinal Study of Bone Mineralisation Characteristics in Marfan Syndrome and Ehlers-Danlos Syndrome

Study acronym: BONE
Not Yet Recruiting
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Record status
This record was last updated September 12, 2025 (before its estimated March 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The general objective of this research is to evaluate the characteristics of bone mineralisation in patients with Marfan syndrome or Ehlers-Danlos syndrome on a large case series. In particular we intend to obtain data regarding the characteristics of bone mineralisation, as well as their variation over time and the relationships existing with other clinical-anamnestic parameters, in patients with Marfan syndrome or Ehlers-Danlos syndrome by retrospectively analysing (data already collected for normal clinical practice and already available at the hospital) the case history of the Cardiovascular genetic center at IRCCS Policlinico San Donato and the related Computerized Bone Mineralometry (MOC) examinations performed at the Radiology Service of the same hospital between 1 September 2019 and 31 December 2022.
Trial Details
NCT Number NCT07169669
Lead Sponsor IRCCS Policlinico S. Donato
Collaborators: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Conditions Marfan Syndrome, Ehlers-Danlos Syndrome (EDS), Mineral Density
Enrollment 150 participants
Start Date 2025-10-31
Primary Completion 2026-03-31 (estimated)
Study Completion 2026-05-31 (estimated)
Updated on ClinicalTrials.gov 2025-09-12