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Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy

Name: Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy — clinical trial record (NCT07076914)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: PPI-PROTECT

StatusNot Yet Recruiting

PhasePhase 2

SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Started2025-10-02

View on ClinicalTrials.gov ↗

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

155 trials monitored

See 11 trials at risk

Lung Cancer

4,033 trials monitored

See 210 trials at risk

Non-Small Cell Lung Cancer (NSCLC)

2,914 trials monitored

See 156 trials at risk

Small Cell Lung Cancer

539 trials monitored

See 30 trials at risk

A randomized controlled trial to assess the impact of prophylactic proton pump inhibitor use to improve esophagitis in lung cancer patients undergoing radiation. Patients will be randomized into a standard of care arm or the prophylactic proton pump (daily) arm.

Trial Details

NCT Number	NCT07076914
Lead Sponsor	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions	Primary Lung Cancer, Non Small Cell Lung Cancer, Small Cell Lung Cancer
Enrollment	58 participants
Start Date	2025-10-02
Primary Completion	2028-01-02 (estimated)
Study Completion	2032-10-02 (estimated)
Updated on ClinicalTrials.gov	2025-07-22