Clinical Trial

SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia

Name: SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia — clinical trial record (NCT07053306)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Recruiting Phase 1

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Summary

To examine the 2-HIT hypothesis that the SGLT2i-induced stimulation of EGP, lipolysis, and ketone production requires the combination of volume depletion plus insulinopenia in T2D individuals.

Protocol Amendment History 2 amendments

This ClinicalTrials.gov record has been amended 2 times since 2025-06-26; most recent amendment 2026-07-15.

Trial Details

NCT Number	NCT07053306
Lead Sponsor	The University of Texas Health Science Center at San Antonio Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions	Type 2 Diabetes
Enrollment	29 participants
Start Date	2025-04-29
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-17