Clinical Trial

BoxX-NoAF Clinical Trial

Recruiting
View on ClinicalTrials.gov →
Summary
Post Operative Atrial Fibrillation (POAF) is the most common complication of cardiac surgery. POAF incidence can exceed 50% depending on the patient baseline characteristics and surgery type. Patients with POAF tend to have worse acute and long-term clinical outcomes. BoxX-NoAF is a randomized trial to evaluate if prophylactic ablation and exclusion of the Left Atrial Appendage at the time of other routine cardiac surgery can reduce the incidence of post operative AF and clinical AF during long term follow up in patients who have not yet developed AF but are at risk.
Protocol Amendment History 4 changes
notable Trial sites expanded: 16 -> 27 locations 2026-06-30
notable Primary completion moved earlier: 2028-11 -> 2027-02 2026-06-30
minor Completion moved earlier: 2031-11 -> 2029-12 2026-06-30
notable Trial sites expanded: 10 -> 16 locations 2026-04-08
Trial Details
NCT Number NCT06989775
Lead Sponsor AtriCure, Inc.
Conditions Post Operative Atrial Fibrillation, Atrial Fibrillation, Postoperative
Enrollment 960 participants
Start Date 2025-10-24
Primary Completion 2027-02 (estimated)
Study Completion 2029-12 (estimated)
Updated on ClinicalTrials.gov 2026-06-29