Clinical Trial

Effectiveness and Acceptability of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in People With Long COVID-19.

Study acronym: UP-LONGCOVID-R
Recruiting
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Summary
This Randomized Controlled Trial (RCT) aims to assess the effectiveness and acceptability of the Unified Protocol (UP) in an online group format for the treatment of emotional disorders in adults. Participants will be 90 adults (45 in the control group and 45 in the experimental group) with diagnosis of long COVID and comorbid emotional disorders. Participants will be recruited at Hospital Royo Villanova from Zaragoza, Spain. In this study it will be explored whether the changes obtained after the intervention in emotional disorders and cognitive complaints are maintained over 12 months. Additionally, levels of chronic stress will be longitudinally evaluated in the experimental group through accumulated cortisol levels in hair, before and after the application of the UP.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-04-14.
Status change: Not Yet Recruiting → Recruiting 2025-05-19
Trial Details
NCT Number NCT06928480
Lead Sponsor Instituto de Investigación Sanitaria Aragón
Collaborators: Hospital Royo Villanova de Zaragoza
Conditions Long Covid-19, Emotional Disorder, Anxiety, Depression Disorders, Emotion Regulation
Enrollment 90 participants
Start Date 2025-05-01
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-05-22