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GLP-1s to Enhance Lasting Optimal Weight

Study acronym: GLOW
StatusActive, Not Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 1 year 1 month later across 2 updates Sep 30, 2026 → Oct 30, 2027
Primary endpoints added 8 → 18 primary endpoints
See other at-risk trials from Wake Forest University Health Sciences

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary completion pushed from Oct 30, 2026 to Oct 30, 2027
    • Primary endpoint(s) modified
    • Primary completion pushed from Sep 30, 2026 to Oct 30, 2026
    • Study completion pushed from Dec 31, 2026 to Dec 31, 2027
  2. Primary completion date: Sep 30, 2026 to Oct 30, 2026
    • Eligibility criteria expanded, about 11 words
  3. Trial status: Recruiting to Active, Not Recruiting
    • Site details revised
    v5
  4. Start date changed from estimate of Jul 2025 to Jul 7, 2025v4
  5. Trial status: Not Yet Recruiting to Recruiting
    • Start date: Jun 2025 to Jul 2025
    • Site details revised
    v3
  6. Start date: May 1, 2025 to Jun 2025v2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this study is to examine how tirzepatide affects body composition, bone health, and physical performance in older adults over a nine-month period. Participants will take tirzepatide weekly, have clinic visits every 4 weeks, meet study doctor and registered dietitian every 4 weeks in person or video conference, attend group intervention sessions twice a month via video conference, weigh daily with a study-provided smart scale, keep a record of all foods and beverages consumed, and use a study-provided activity tracker to keep track of daily step counts.
Trial Details
NCT Number NCT06861439
Lead Sponsor Wake Forest University Health Sciences
Conditions
(from sponsor)		 Obesity
Related terms Muscular Atrophy, Obesity, Weight Loss
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov